Tuesday, 3rd June Hunter Cell Biology Meeting 2025

• Targeting quiescent glioma stem cells: lessons from neural stem cell biology - Lachlan Harris
• Programming age into stem cell models of neurodegenerative disease - Nathalie Saurat
• Hypoxic injury triggers maladaptive repair in human kidney organoids - Alexander N Combes
• Spatiotemporal identification and lineage tracing of Mesendoderm progenitor cells in mammalian embryo - V. Pragathi Masamsetti
• Loss of the transcriptional repressor Hfp promotes stem cell niche escape - Teresa Bonello

• Exploring the impact of the tumour microenvironment and therapy on breast cancer cell fate - Delphine Merino
• The emergence of “dark” kinases as underappreciated signaling effectors and therapeutic targets - James M Murphy
• Ubiquitination beyond protein - David Komander
• Pro-neurotrophic compounds promote neurogenesis and synaptogenesis to mitigate age-related cognitive decline. - Sevannah A Ellis
• Highly multiplexed cellular imaging reveals the true dynamics underpinning EMT and how EM-states modulate cellular perception of incoming ligand signals - John G Lock

• Spatial transcriptomics: how to start and what to do once you get the data - Anna Trigos
• Evaluating computational methods for detecting spatially variable genes in spatial transcriptomics data analysis - Pengyi Yang

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• Characterisation the role of Caveolar coat proteins in breast cancer. - Le H.M. Nguyen
• Integrin adhesion complexes protect sensory axons from damage - Zijie Li
• Conserved phosphorylation of the Myosin1e TH1 domain regulates membrane association and function in yeast and worms. - Daniel Mulvihill
• Mitochondrial function regulates cellular growth rates to actively maintain mitochondrial homeostasis in dividing cells - Vaishnavi Ananthanarayanan
• _{Intracellular pH contributes to signal complexity of mitogen-activated protein kinases.} - Dominic Ng
• The second polar body establishes the first fate asymmetry in mouse embryos - Hongbin Jin
• Spectrin forms a periodic cytoskeleton within the epidermis to preserve axonal integrity   - Sean Coakley
• Neural crest cell derived DKK1 modulates Wnt signalling in the second heart field to orchestrate cardiac outflow tract development - Sophie Wiszniak
• Distinct topography of the primary sclerosing cholangitis colonic mucosa defined through paired microbial and single-cell RNA sequencing - Jacqueline LE Tearle
• Squamous cell carcinoma malignancy can be determined by miR-10b expression - Chen Wang
• Cholesterol trafficking from the plasma membrane to the endoplasmic reticulum: control by the phosphatidylserine transporters ORP5/8 - Fanqian N. Xiao
• Alternate lipid uptake mechanisms in prostate cancer - Madison T Hindes
• Presynapses are mitophagy pit stops that prevent axon degeneration - Wai Kit (Leo) Lam
• Targeting the NPY/NPY1R signaling axis impairs metastasis and tissue wasting in pancreatic cancer - David Herrmann
• An optimized explant organoid method for preclinical brain tumour research - Helen M. Palethorpe
• non-PCP Roles of Prickle1 in Neural Tube Formation and Disease - Samara Ranie
• RNA export factors safeguarding the embryonic genome - William B Hamilton
• Non-radial chromatin architectures emerge during confined cell migration - Hann Shen Ng
• Long-Term, Photogentle Imaging of Mitochondrial Dynamics - Sanjeev SU Uthishtran
• Role of spatial confinement in guiding primordial germ cell migration and fate specification - Malhar S Chitnis
• Characterisation of the secretory lysosome proteome reveals new regulators of osteoclast fusion, function and endolysosomal homeostasis - Jasreen Kular
• GWAS-empowered characterization of a long non-coding RNA gene as a sequence-based drug target in human type 2 diabetes using an in vivo nonhuman primate model - Leonard Lipovich
• Adult Drosophila salivary gland cells exhibit alternative polarity and mode of cell division - Gary R Hime
• Synapsin 2a tetramerisation selectively controls the nanoscale clustering of reserve synaptic vesicles at the hippocampal presynapse - Shanley F Longfield
• Towards re-engineering development in vivo - Marcus G Heisler
• Role of polarized exocytosis in infection of host cells by enteropathogenic E. coli - Thilina Herath Mudiyanselage
• Time-resolved multi-omics uncovers the complex impact of DNA replication stress on pluripotency loss and developmental programs - Osvaldo Contreras
• MitoMimics – Synthetic Microscopy Data for Deep-Learning Segmentation and Tracking of Mitochondrial Dynamic  - Vijay A Prof. Rajagopal
• Dynamic, quantitative 3D imaging defines peptide uptake and biodelivery routes in macrophages and reveals disease-associated vulnerabilities. - Hongyu Shen
• Stem cell dynamics in intestinal regeneration and disease - Helen E Abud

• Harnessing actin assembly forces to drive endocytic vesicle formation - David Drubin

• The innate immune mediator group IIA secreted phospholipase A₂ modulates lipid droplet formation in prostate cancer cells. - Monavvar Andarva
• How nephrogenesis is impacted by maternal nutrition. - Kieran Short
• An ancient interplay between Scribble, Dlg and Vangl controls regeneration in the simplest animal on earth, Trichoplax - Patrick O Humbert
• ROCK activity enhances intestinal tumour progression, partly by establishing a permissive microenvironment - Zahied Johan
• Decoding the mechano-metabolic landscape of cell migration through quantitative modelling - Volkan Ozcoban
• The cell surface protein, Dscam2, regulates trafficking pathways required for memory formation - Sean Millard
• Open-top multi-sample dual-view light-sheet microscope for live imaging of large multicellular systems - Shelly Azadi
• Systematic characterisation of the neuroprotective role of spectrin in glia. - Dat Le
• De novo protein myristoylation mediates synaptic plasticity and long-term potentiation through membrane association of synaptic proteins  - Ben S Matthews
• Spatial transcriptomic analysis of Wnt4-KO mice reveals novel cellular interactions essential for kidney development - Harrison A. Mueller
• BRCA1 vs. 53BP1: Balancing Chromatin Structure and Mobility in DNA Repair - Jieqiong Lou
• Macrophages-derived Extracellular Vesicles Modulate Stem Cell Functions During Muscle Regeneration In Zebrafish - Quoc Duy Tran
• Tmem161b is required for proper endoplasmic reticulum morphology - Nicole Dominado
• Eukaryotic-specific post-transcriptional regulatory networks emerged at the base of eukaryogenesis. - Balu Balan
• Dynamic regulation of telomere elongation during preimplantation embryogenesis is perturbed by oxidative stress. - Yasmyn E Winstanley
• CSPG4 as a driver of malignancy in aggressive squamous cell carcinoma - Jasmine M Zhou
• IMAGING ACROSS SCALES – CATCHING ORGANELLE DYNAMICS IN LIVING TISSUES - Senthil Arumugam
• Drug targeting of colorectal cancers including cancer stem cells - Reem ALHulais
• Understanding the role of pericytes in controlling blood brain barrier maintenance using both zebrafish and mouse brain pericyte deficient models. - Alison Farley
• Mapping Glucose-Driven Lipid Biogenesis in Bone Marrow Adipocytes: Implications for Osteoporosis Therapy - Kai Chen
• Uncovering genetic and non-genetic mechanisms of phenotypic variation - Sebastian Dworkin
• Re-shaping the Pancreatic Cancer Tumour Microenvironment: The Metastasis Suppressor NDRG1 Inhibits Pancreatic Cancer Exosome Release, Biogenesis, Packaging, and Uptake   - Jiawei Chang
• FUBP1 and CIC function in the glial niche to prevent neural stem cell overproliferation - Olga Zaytseva
• Epigenetic consequences of ROCK1/2 kinase inhibitor Y27632 in pluripotent stem cell culture - Matt Neve
• Viral-mediated neuronal fusion: A novel alteration of the nervous system's architecture. - Ramon Martinez-Marmol
• The role of KANLIKE1 and KANLIKE2 genes in leaf development - Hiruni Fernando
• Tau biomolecular condensates induce nanoscale sequestering: A novel mechanism to control synaptic function and Fyn activity. - Ramon Martinez-Marmol
• Mitochondrial dynamics in gastrulation: regulation of ventral furrow formation by Dynamin related protein 1 - Somya Madan
• A single cell view of Müllerian duct development. - Juan L Tan
• 3D cartography of emerging haematopoietic stem cells in the mammalian embryo - Jan Manent
• Dissecting the cellular effects of psychedelics on serotonin receptor signalling. - Gregory Redpath
• Proximity proteomics and structural screens provide insights into the functional components of the Retromer endosomal membrane domain - Brett Collins